Resumed Underperform X

SAGE SAGE Therapeutics

BofA Securities

$5

Upgrades Underperform Sec Perform X

SAGE SAGE Therapeutics

RBC Capital Mkts

$4

Resumed Mkt Perform X

SAGE SAGE Therapeutics

Raymond James

Downgrades Outperform Sec Perform X

SAGE SAGE Therapeutics

RBC Capital Mkts

$10 $4

Downgrades Buy Hold X

SAGE SAGE Therapeutics

TD Cowen

$16 $10

Downgrades Overweight Neutral X

SAGE SAGE Therapeutics

JP Morgan

$18 $12

Initiated Sell X

SAGE SAGE Therapeutics

Citigroup

$8

Initiated Neutral X

SAGE SAGE Therapeutics

Robert W. Baird

$15

Downgrades Neutral Underperform X

SAGE SAGE Therapeutics

BofA Securities

$24 $14

Initiated Hold X

SAGE SAGE Therapeutics

Deutsche Bank

$21

Downgrades Buy Hold X

SAGE SAGE Therapeutics

Canaccord Genuity

$64 $21

Downgrades Buy Neutral X

SAGE SAGE Therapeutics

Goldman

$22

Downgrades Buy Hold X

SAGE SAGE Therapeutics

Needham

Downgrades Buy Neutral X

SAGE SAGE Therapeutics

BofA Securities

$66 $25

Downgrades Outperform Perform X

SAGE SAGE Therapeutics

Oppenheimer

Downgrades Outperform Sec Perform X

SAGE SAGE Therapeutics

RBC Capital Mkts

$71 $25

Downgrades Buy Hold X

SAGE SAGE Therapeutics

Stifel

$60 $22

Downgrades Outperform Neutral X

SAGE SAGE Therapeutics

Wedbush

$51 $22

Initiated Sector Outperform X

SAGE SAGE Therapeutics

Scotiabank

Upgrades Sec Perform Outperform X

SAGE SAGE Therapeutics

RBC Capital Mkts

$40 $60

Downgrades Buy Neutral X

SAGE SAGE Therapeutics

Guggenheim

Initiated Hold X

SAGE SAGE Therapeutics

Loop Capital

$41

Initiated Hold X

SAGE SAGE Therapeutics

Berenberg

$37

Resumed Equal-Weight X

SAGE SAGE Therapeutics

Morgan Stanley

$78 $66

Downgrades Buy Hold X

SAGE SAGE Therapeutics

Jefferies

$100 $50

Downgrades Buy Neutral X

SAGE SAGE Therapeutics

Citigroup

$101 $68

Initiated Overweight X

SAGE SAGE Therapeutics

Piper Sandler

$100

Downgrades Buy Neutral X

SAGE SAGE Therapeutics

Mizuho

$81

Reiterated Neutral X

SAGE SAGE Therapeutics

H.C. Wainwright

$74 $86

Resumed Mkt Perform X

SAGE SAGE Therapeutics

Raymond James

Downgrades Outperform Mkt Perform X

SAGE SAGE Therapeutics

BMO Capital Markets

$95

Upgrades Neutral Buy X

SAGE SAGE Therapeutics

Guggenheim

Downgrades Outperform Sec Perform X

SAGE SAGE Therapeutics

RBC Capital Mkts

$83 $86

Initiated Outperform X

SAGE SAGE Therapeutics

Wedbush

Initiated Buy X

SAGE SAGE Therapeutics

Jefferies

$195

Initiated Outperform X

SAGE SAGE Therapeutics

Wolfe Research

Initiated Outperform X

SAGE SAGE Therapeutics

Oppenheimer

$170

Reiterated Buy X

SAGE SAGE Therapeutics

Stifel

$198 $239

Initiated Overweight X

SAGE SAGE Therapeutics

Piper Jaffray

$206

Initiated Buy X

SAGE SAGE Therapeutics

Ladenburg Thalmann

$230

Resumed Buy X

SAGE SAGE Therapeutics

Canaccord Genuity

$210

Initiated Overweight X

SAGE SAGE Therapeutics

Morgan Stanley

SAGE  Sage Therapeutics, Inc.

SAGE Therapeutics, Inc. is a clinical-stage biopharmaceutical company. The Company is engaged in developing and commercializing medicines to treat central nervous system (CNS) disorders. The Company's lead product candidate, SAGE-547 is an intravenous formulation of allopregnanolone, a neurosteroid that acts as a synaptic and extrasynaptic modulator of the Gamma-Amino Butyric Acid-A (GABAA) receptor. The Company's next-generation product candidates, SAGE-217 and SAGE-689, also target the GABAA receptor system. The Company is focused on developing drugs based on selective allosteric modulation of CNS synaptic and extrasynaptic receptors. The Company's chemistry platform is focused on the chemical scaffolds of endogenous or chemically modified synthetic neuroactive steroid compounds that are allosteric modulators of GABAA or N-Methyl-D-aspartic acid or N-Methyl-D-aspartate (NMDA) receptors.