Downgrades Peer Perform Underperform X

ALNY Alnylam Pharma

Wolfe Research

Initiated Sector Outperform X

ALNY Alnylam Pharma

Scotiabank

Upgrades Neutral Buy X

ALNY Alnylam Pharma

Goldman

$198 $370

Downgrades Buy Neutral X

ALNY Alnylam Pharma

Goldman

$173

Initiated Peer Perform X

ALNY Alnylam Pharma

Wolfe Research

Initiated Equal Weight X

ALNY Alnylam Pharma

Wells Fargo

$171

Downgrades Outperform Perform X

ALNY Alnylam Pharma

Oppenheimer

Initiated Outperform X

ALNY Alnylam Pharma

Raymond James

$208

Upgrades Mkt Perform Outperform X

ALNY Alnylam Pharma

BMO Capital Markets

$200 $250

Initiated Neutral X

ALNY Alnylam Pharma

SMBC Nikko

$220

Initiated Outperform X

ALNY Alnylam Pharma

Bernstein

$243

Initiated Buy X

ALNY Alnylam Pharma

Canaccord Genuity

$310

Resumed Equal-Weight X

ALNY Alnylam Pharma

Morgan Stanley

$222

Initiated Neutral X

ALNY Alnylam Pharma

Cantor Fitzgerald

$175

Downgrades Buy Neutral X

ALNY Alnylam Pharma

Guggenheim

Initiated Outperform X

ALNY Alnylam Pharma

William Blair

Downgrades Overweight Eq-Weight X

ALNY Alnylam Pharma

Morgan Stanley

$210 $178

Upgrades Neutral Buy X

ALNY Alnylam Pharma

Guggenheim

$170

Upgrades Neutral Overweight X

ALNY Alnylam Pharma

Piper Sandler

$181 $208

Upgrades Neutral Buy X

ALNY Alnylam Pharma

Goldman

$273

Upgrades Sec Perform Outperform X

ALNY Alnylam Pharma

RBC Capital Mkts

$144 $225

Upgrades Perform Outperform X

ALNY Alnylam Pharma

Oppenheimer

$200

Upgrades Neutral Buy X

ALNY Alnylam Pharma

UBS

$141 $215

Downgrades Buy Neutral X

ALNY Alnylam Pharma

Guggenheim

$162

Downgrades Buy Neutral X

ALNY Alnylam Pharma

Citigroup

$170 $175

Reiterated Buy X

ALNY Alnylam Pharma

H.C. Wainwright

$225 $235

Downgrades Outperform Mkt Perform X

ALNY Alnylam Pharma

BMO Capital Markets

$185

Resumed Neutral X

ALNY Alnylam Pharma

Goldman

$80

Initiated Outperform X

ALNY Alnylam Pharma

Evercore ISI

Upgrades Eq-Weight Overweight X

ALNY Alnylam Pharma

Morgan Stanley

Initiated Neutral X

ALNY Alnylam Pharma

UBS

$87

Initiated Overweight X

ALNY Alnylam Pharma

Cantor Fitzgerald

$135

Reiterated Buy X

ALNY Alnylam Pharma

Stifel

$125 $123

Upgrades Hold Buy X

ALNY Alnylam Pharma

Stifel

$95 $125

Reiterated Hold X

ALNY Alnylam Pharma

Stifel

$107 $95

Initiated In-line X

ALNY Alnylam Pharma

Evercore ISI

Reiterated Mkt Outperform X

ALNY Alnylam Pharma

JMP Securities

$169 $207

Reiterated Buy X

ALNY Alnylam Pharma

B. Riley FBR, Inc.

$205 $200

ALNY  Alnylam Pharmaceuticals, Inc.

Alnylam Pharmaceuticals, Inc. is a biopharmaceutical company. The Company is engaged in the discovery, development and commercialization of ribonucleic acid (RNA) interference (RNAi) therapeutics. The Company is focused on the use of its N-acetylgalactosamine (GalNAc)-conjugate platform for delivery of small interfering RNAs (siRNAs). Its pipeline of investigational RNAi therapeutics focuses on three Strategic Therapeutic Areas (STArs): Genetic Medicines, with multiple product candidates for the treatment of rare diseases; Cardio-Metabolic Diseases, with product candidates directed toward genetically validated, liver-expressed disease targets for unmet needs in cardiovascular and metabolic diseases, and Hepatic Infectious Diseases, with product candidates designed to address the global health challenges of hepatic infectious diseases, beginning with hepatitis B and hepatitis D viral infections. The Company's lead product, Patisiran, is formulated utilizing lipid nanoparticles (LNPs).